Journal Paper

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Journal: پژوهشی خون
Year:1395 | Volume:13 | Issue:1
Start Page:11 | End Page:18

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Title

OXIDATIVE STRESS CHANGES IN BLOOD BAGS IN CONSECUTIVE WEEKS AFTER DONATION

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 Start Page 11 | End Page 18

Abstract

 Background and Objectives: The oxidative stress destroys the red blood cells during preservation. The awareness about the stress oxidative process is important for the safety of blood bags and patients. The aim of the study was to evaluate the pro-oxidant-antioxidant balance (PAB) and SUPEROXIDE DISMUTASE (SOD) and GLUTATHIONE PEROXIDASE (GPX) enzymes in blood bags in the weeks after donation.Materials and Methods: In a descriptive study, a number of 100 blood bags were used for the blood donors between 18 to 57 years of age (the mean age of 35.5) in Bojnourd Blood Center. The blood bags were kept in standard conditions for 6 weeks and the adequate samples were taken for test. The test included PAB, SOD, and GPX and the repeated measures analysis was performed.Results: The pro-oxidant-antioxidant balance had a significant increase (p<0.000). Enzymes like SOD and GPX had a significant decrease (p<0.000).Conclusions: Results showed that pro-oxidant-antioxidant balance and antioxidant enzyme activities changed particularly in the first two weeks. Therefore, it is suggested that for the diseases related with oxidative stress such as cardiovascular diseases, diabetes, and cancers, patients receive blood stored less than two weeks.

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