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Title

RELATIONSHIP BETWEEN -5T/C POLYMORPHISM OF PLATELET GP1BA GENE PROMOTER AND PREMATURE ACUTE MYOCARDIAL INFARCTION IN PATIENTS REFERRED TO RAJAEE HEART CENTER

Pages

 Start Page 27 | End Page 35

Keywords

POLYMORPHISM (GENETICS)Q3

Abstract

 Background and Objectives: Some platelet membrane GLYCOPROTEIN gene polymorphisms have been reported as potential factors related to cardiovascular complications. Recently, the -5T/C polymorphism located at the initiation element (Kozak sequence) of the platelet GLYCOPROTEIN Iba (GPIba) translation was suggested to increase the platelet surface levels of GP Ib-IX-V receptor; however, its function in the occurrence of arterial thrombotic disease is unknown. In this study, we evaluated the role of the GP Iba -5T/C polymorphism in premature myocardial infraction among Iranian patients.Materials and Methods: Two hundred subjects who underwent coronary angiography were studied on the basis of the study protocol through 2010. Patients (n=100) selected by WHO criteria and matched on age parameter with controls (n=100; Men<50 years old and Women >55 years old). The genotype distribution of GP Iba -5T/C polymorphism was evaluated by PCR-RLFP technique.Results: There were no significant differences in age, hypertension, and diabetes between the patients and controls. However, the sex, family history of CAD, smoking and hyperlipidemia had a significant difference between the two groups. The allele frequencies of C and T were calculated to be 0.13 and 0.87, respectively. In addition, the CC genotype showed to be a potential factor for the occurrence of MYOCARDIAL INFARCTION (p=0.56, OR=3.06, CI (95%) = 0.31-29.94).Conclusions: Although no significant association was observed between the - 5C/T polymorphism and premature myocardial infraction, we considered that the C allele may be an effective factor for premature myocardial infraction.

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