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Title

INVESTIGATION OF C-C CHEMOKINE RECEPTOR TYPE 4 (CCR4) GENE POLYMORPHISM IN PATIENTS WITH GESTATIONAL TROPHOBLASTIC DISEASES (GTD)

Pages

 Start Page 262 | End Page 271

Keywords

GTDQ2

Abstract

 Introduction & Objective: Gestational trophoblastic disease (GTD) consists of a spectrum of disorders that are characterized by an abnormal proliferation of trophoblastic tissue, following an abnormal fertilization. CCR4 is one chemo-attractant receptors preferentially expressed on Th2 cells, and therefore, is likely to participate in the recruitment of antigen-specific Th2 cells to sites of allergen exposure. Variations in CCR4 have been reported. In this study we intended to investigate the relationship between POLYMORPHISM of this particular gene at the site of 1014 C/T and GTD.Materials & Methods: In the present study, the POLYMORPHISMs of the CCR4 gene at the sites of 1014 C/T was investigated in 100 patients at in 2010 with proved GTD and 120 age-sex matched healthy individuals. Polymorphysm of CC chemokine 4 were investigated in these two groups by PCR-RFLP. These two groups were compared in respect their GENOTYPEs and alleles.Results: Frequency of GENOTYPE TT, CT, CC patients were 34%, 62% and 4% while the frequency of the control group, were 46.7%, 35.8% and 17.5% respectively.A significant difference was seen in GENOTYPE prevalence of 1014 C/T in CCR4 gene in the two mentioned groups (P<0.05). No statically significant difference was seen in allele 1014 C/T in CCR4 gene in the two mentioned groups (P>0.05).Conclusion: Regarding the relationship between The C-C chemokine receptor type 4 and gestational trophoblastic disease (GTD), it might be possible to use this gene as a prognostic marker in identifying the susceptible patients.

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