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Title

EFFECT OF ETHANOLIC EXTRACT OF CYDONIA OBLONGA SEED ON THE HEALING OF SECOND-DEGREE BURN WOUNDS

Pages

 Start Page 494 | End Page 501

Abstract

 Background & aim: It has been shown that antioxidants may contribute to the HEALING of wounds caused by BURNs. This study was designed to determine the effects of the ethanolic EXTRACT of CYDONIA OBLONGA seeds on second degree BURN wounds.Methods: In a preclinical study, 48 mice were divided into 4 groups of 12. Group-I (sham) received no treatment, Group- II (negative control) was treated with Vaseline, Groups-III was treated with 1% CYDONIA OBLONGA seed ointment and Group IV (positive control) received silver sulphadiazine twice per day. In the treatment groups, 1 gr ointment twice per day until complete wound HEALING was used. Animals were assessed by measuring the percent of wound HEALING, the remained gap of incision injury and total time required for complete HEALING. The data were statistically analyzed with SPSS software using one-way ANOVA and Tukey’s tests.Results: The results showed that concentration of 1% of CYDONIA OBLONGA seed EXTRACT had significantly better BURN wound HEALING effects (99.502%) in treatment group in comparison with the control group (92.97%).This is because the percentage of BURN HEALING was higher and the length of HEALING was shorter in CYDONIA OBLONGA seed group compared to the control groups (P<0.05).Conclusion: The results showed that the CYDONIA OBLONGA seed ointment might be beneficial in patients with second degree BURN wounds. Further studies are recommended to establish the optimal dose of the EXTRACT.

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