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Title

Efficacy of Fluconazole Prophylaxis on Invasive Candidiasis Infection in Extremely Low Birth Weight Neonates

Pages

  86-91

Abstract

 Background: Invasive candidiasis infection is one of the main life-threatening problems for Extremely low birth weight (ELBW) neonates who are in the neonatal intensive care unit (NICU). Candidiasis can cause mortality, shortterm morbidity, and long-term neurodevelopmental outcome in infected infants who survive. Therefore, since several years ago Fluconazole Prophylaxis has begun for premature newborns who were admitted to NICUs in some parts of the world. Methods: In this retrospective cohort, the population study was all the infants of less than 1, 000 gram admitted to Valiasr Hospital during the years 2011-2016. The subjects were divided into two groups of control and intervention. The control group did not receive any Fluconazole Prophylaxis, while for the test group, intravenous Fluconazole was administered. Finally, we compared the incidence of candidiasis between the two groups. Results: Fluconazole was administered to 70 out of 167 neonates. Our indings showed that two infants of the Prophylaxis group (2. 9%) and two (1. 2%) of the non-Prophylaxis group were infected with Candida species. The difference between the two groups was not statistically signi icant (P=0. 501). Among the risk factors, bacterial sepsis, the duration of central catheter installation, total parenteral nutrition, meropenem or vancomycin administration, and hospitalization costs were significantly related to the incidence of Invasive candidiasis infection. Conclusion: The incidence of candidiasis in our study was 2. 39% and luconazole Prophylaxis has not been effective in reducing fungal infections. Consequently, further investigations in larger sample sizes with different study settings and a variety of methodologies are needed to evaluate the efficacy of Fluconazole Prophylaxis on Invasive candidiasis infection in ELBW neonates.

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    APA: Copy

    DALILI, HOSEIN, NIKNAFS, NIKOO, SHARIAT, MAMAK, Moradi, Raheleh, Charousaei, Hasti, AMINI, ELAHEH, Moeini, Roksana, Akhondzadeh, Afsaneh, & Naddaf, Amir. (2020). Efficacy of Fluconazole Prophylaxis on Invasive Candidiasis Infection in Extremely Low Birth Weight Neonates. IRANIAN JOURNAL OF NEONATOLOGY, 11(1), 86-91. SID. https://sid.ir/paper/765394/en

    Vancouver: Copy

    DALILI HOSEIN, NIKNAFS NIKOO, SHARIAT MAMAK, Moradi Raheleh, Charousaei Hasti, AMINI ELAHEH, Moeini Roksana, Akhondzadeh Afsaneh, Naddaf Amir. Efficacy of Fluconazole Prophylaxis on Invasive Candidiasis Infection in Extremely Low Birth Weight Neonates. IRANIAN JOURNAL OF NEONATOLOGY[Internet]. 2020;11(1):86-91. Available from: https://sid.ir/paper/765394/en

    IEEE: Copy

    HOSEIN DALILI, NIKOO NIKNAFS, MAMAK SHARIAT, Raheleh Moradi, Hasti Charousaei, ELAHEH AMINI, Roksana Moeini, Afsaneh Akhondzadeh, and Amir Naddaf, “Efficacy of Fluconazole Prophylaxis on Invasive Candidiasis Infection in Extremely Low Birth Weight Neonates,” IRANIAN JOURNAL OF NEONATOLOGY, vol. 11, no. 1, pp. 86–91, 2020, [Online]. Available: https://sid.ir/paper/765394/en

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