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Title

Prevalence of resistance and toxin genes in community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolates

Pages

  1251-1260

Abstract

 Objective(s): Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major health hazards and became of greater public health concern since the emergence of Community-acquired MRSA. This work aimed to study the prevalence of mecA, femA, femB, lukS-PV, lukF-PV (PVL), intI, and intII genes among Community-acquired (CA) Hospital-acquired (HA) MRSA to increase vigilance in the diagnosis and management of suspected infections. Materials and Methods: S. aureus isolates recovered from clinical samples were classified into Community or Hospital-acquired and tested for their antibiotic susceptibility against 19 antibiotics. All isolates were screened for mecA, femA, femB, lukS-PV, lukF-PV, intI, and intII genes. Statistical correlations were carried out. Results: Out of 338 S. aureus isolates, only 105 were MRSA and classified as 77 CA-MRSA and 28 HAMRSA. mecA and femA genes were present in all HA-MRSA and CA-MRSA isolates. femB was found in all HA-MRSA and 93. 5% of CA-MRSA isolates. PVL genes were detected in 28. 6% HA-MRSA isolates and 92. 2% CA-MRSA. intI gene was recovered from 60. 7% HA-MRSA isolates and 37. 7% CA-MRSA isolates while the intII gene recovered from only 10. 7% HA-MRSA isolates and 6. 5% CA-MRSA. Conclusion: The high prevalence of MRSA colonizing the groin, axilla, and nose may play a significant role in endogenous infection, re-infection, and also acts as a route for MRSA transmission. mecA and femA genes could be used as a sole and fast step for identification of MRSA, while PVL genes cannot be used as a sole stable marker for CA-MRSA identification.

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    APA: Copy

    El Baghdady, Khaled Z., El Borhamy, Mervat I., & Abd El Ghafar, Hisham A.. (2020). Prevalence of resistance and toxin genes in community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolates. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 23(10), 1251-1260. SID. https://sid.ir/paper/756712/en

    Vancouver: Copy

    El Baghdady Khaled Z., El Borhamy Mervat I., Abd El Ghafar Hisham A.. Prevalence of resistance and toxin genes in community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolates. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2020;23(10):1251-1260. Available from: https://sid.ir/paper/756712/en

    IEEE: Copy

    Khaled Z. El Baghdady, Mervat I. El Borhamy, and Hisham A. Abd El Ghafar, “Prevalence of resistance and toxin genes in community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolates,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 23, no. 10, pp. 1251–1260, 2020, [Online]. Available: https://sid.ir/paper/756712/en

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