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Information Journal Paper

Title

The Relationship between Pesticide Exposure and Umbilical Serum IGF-1 Levels and Low-birth Weight: A Case-control Study in Brebes, Indonesia

Pages

  15-23

Abstract

 Background: Birth weight is very important for long-term physical, mental, health, and brain development. Pesticide exposure is thought to interfere with fetal growth, among others, through disruption of the function of the insulin-like growth hormone-1 (IGF-1) hormone. Objective: To analyze the relationship between exposure to Pesticides during pregnancy and low-birth weight (LBW) through the disruption of the IGF-1 hormone. Methods: In a case-control study, babies born with LBW (birth weight <2500 g) and those born later with normal birth weight (≥ 2500 g) at 2 hospitals in Brebes were chosen as cases and controls, respectively. Maternal pesticide exposure was measured by interview using a questionnaire. Umbilical serum IGF-I level was tested using the ELISA method. Results: There was a significant relationship between pesticide exposure during pregnancy and LBW (OR 6. 8; 95% CI 2. 0 to 22. 9) and low umbilical serum IGF-1 levels (OR 3. 6; 95% CI 1. 2 to 11. 1). There was a significant relationship between low umbilical serum IGF-1 levels and LBW (OR 8. 9; 95% CI 2. 4 to 32. 1). Conclusion: There was a significant relationship between pesticide exposure during pregnancy and LBW through the umbilical serum IGF-1 reduction pathway.

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    APA: Copy

    Widyawati, Sigit Ambar, SUHARTONO, SUHARTONO, Mexitalia, Maria, & Soejoenoes, Ariawan. (2020). The Relationship between Pesticide Exposure and Umbilical Serum IGF-1 Levels and Low-birth Weight: A Case-control Study in Brebes, Indonesia. INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 11(1), 15-23. SID. https://sid.ir/paper/753284/en

    Vancouver: Copy

    Widyawati Sigit Ambar, SUHARTONO SUHARTONO, Mexitalia Maria, Soejoenoes Ariawan. The Relationship between Pesticide Exposure and Umbilical Serum IGF-1 Levels and Low-birth Weight: A Case-control Study in Brebes, Indonesia. INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE[Internet]. 2020;11(1):15-23. Available from: https://sid.ir/paper/753284/en

    IEEE: Copy

    Sigit Ambar Widyawati, SUHARTONO SUHARTONO, Maria Mexitalia, and Ariawan Soejoenoes, “The Relationship between Pesticide Exposure and Umbilical Serum IGF-1 Levels and Low-birth Weight: A Case-control Study in Brebes, Indonesia,” INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, vol. 11, no. 1, pp. 15–23, 2020, [Online]. Available: https://sid.ir/paper/753284/en

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