Journal Paper

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Journal: PHYSIOLOGY AND PHARMACOLOGY | Year:1390 | Volume:15 | Issue:4 | Start Page:478 | End Page:485

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Title

EVALUATION OF THE EFFECTS OF TAURINE ON CISPLATIN-INDUCED KIDNEY INJURY AND OXIDATIVE STRESS IN MALE RATS

Writers

NOROZI MARYAM | ZARE SAMAD

Pages

 Start Page 478 | End Page 485

Abstract

 Introduction: CISPLATIN is used as a chemotherapeutic agent for the treatment of human ovarian and testicular cancers. This study was designed to investigate the protective role of TAURINE against CISPLATIN-induced KIDNEY INJURY.Methods: Male Wistar RATs were divided into 4 groups (n=8) (1) saline-treated group (2) CISPLATIN-treated group (10 mg/kg, i.p.), (3) group that received TAURINE (200 mg/kg, i.p) 1 hr before CISPLATIN (10 mg/kg, i.p) administration and (4) TAURINE treated group (200 mg/kg, i.p). The treatment period was 7 days. Animals were then weighed and blood samples were collected from the heart. After sacrifice, kidneys were removed and kept at -70oC until further analyses.Results: CISPLATIN significantly elevated the creatinine and blood urea nitrogen (BUN) serum levels (P<0.05). Pretreatment with TAURINE resulted in a remarkable reduction of these markers. The catalase activity in CISPLATIN-treated RATs was significantly decreased (P<0.05) and TAURINE administration could remarkably recover this decreased activity. Malondialdehyde (MDA) content of the kidneys was increased in CISPLATIN-exposed animals and TAURINE significantly reduced the amount of MDA.Conclusion: Our data suggest that pretreatment with TAURINE might be considered as a protective approach in CISPLATIN-induced nephrotoxicity.

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