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Information Journal Paper

Title

Molecular mechanisms of omega-3 fatty acids in the migraine headache

Pages

 Start Page 210 | End Page 217

Abstract

Migraine is a common chronic inflammatory neurological disease with the progressive and episodic course. Much evidence have shown a role of inflammation in the pathogenesis of Migraine. Omega-3 fatty acids are an important components of cell membranes phospholipids. The intake of these fatty acids is related to decrease concentration of C-reactive protein (CRP), proinflammatory eicosanoids, cytokines, chemokines and other inflammation biomarkers. Many of clinical trials have shown the beneficial effect of dietary supplementation with omega-3 fatty acids in inflammatory and autoimmune diseases in human, including Parkinson’ s disease (PD), amyotrophic lateral sclerosis (ALS), Alzheimer’ s disease (AD), multiple sclerosis (MS) and Migraine Headaches. Therefore, omega-3 fatty acids as an alternative therapy can be potentially important. This review focuses on the pathogenesis of a Migraine, with an emphasis on the role of omega-3 fatty acid and its molecular mechanisms.

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