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Information Journal Paper

Title

COMPARISON OF SERUM VITAMIN D LEVEL IN MULTIPLE SCLEROSIS PATIENTS, THEIR SIBLINGS, AND HEALTHY CONTROLS

Pages

 Start Page 81 | End Page 85

Abstract

 Background: MULTIPLE SCLEROSIS (MS) is an autoimmune, neuro-inflammatory disease of central nervous system affecting physical, emotional, and cognitive aspects of patients. Association of VITAMIN D deficiency and MS has been shown in previous studies. The aim of this study was to evaluate serum VITAMIN D level in MS cases and their sex-matched healthy SIBLINGS (who are genetically near similar) and non-relative sex-matched healthy controls. Methods: A total of 135 subjects enrolled in this casecontrol study. Group one (n = 45) consisted of patients with established MS. Group two (n = 45) included sexmatched healthy SIBLINGS of the group one and group three participants (n = 45) were non-relative sexmatched healthy controls. Demographic data (age, sex), level of education, daily sun exposure duration, and month of birth gathered for all. Serum sample of all participants was collected for 25-hydroxy VITAMIN D measurement. Results: There was no significant difference between VITAMIN D level, sun exposure duration, education level, and season of birth in three evaluated groups. Mean VITAMIN D level was 8. 2 ± 10. 1 (nmol/l) in women and 13. 3 ± 7 (nmol/l) in men (P = 0. 001). There was a significant positive correlation between daily sun exposure duration and VITAMIN D level in whole participants (r = 0. 28, P < 0. 001) as well as in MS patients (r = 0. 32, P = 0. 030). Mean VITAMIN D level was significantly lower in participants who have born in spring and summer. Conclusion: VITAMIN D deficiency is high among Iranian population as well as MS patients.

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