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Title

FEASIBILITY STUDY OF RADIUM-223 PRODUCTION IN TEHRAN RESEARCH REACTOR FOR TREATMENT OF BONE METASTASES

Pages

 Start Page 30 | End Page 36

Abstract

 BONE METASTASIS is a major clinical concern that can cause severe pain, bone fractures, spinalcord compression, hypercalcemia and other problems for patients. Variuos β emitter radionuclides havebeen used for bone pain palliation, but recently α emitter radionucliedes also have shown acceptable resultsof treatment of BONE METASTASIS. RADIUM-223 (t1/2=11.43 d) is one of the suitable α emitters that emits highenergy α particles (Ēav=5.64 MeV) with high linear energy transfer (LET) that delivers a killing dose to thetumor cells. In this research, the feasibility of production of RADIUM-223 from radium-226 was studied inTehran Research Reactor (TRR) in thermal neutron flux of 4×1013 cm-2 s-1 using MATLAB software.Then, the data were compared with the experimental results. On average, over 80 percent agreement wasobserved between the calculated and experimental data, and under appropriate conditions the acceptableactivity of 227Ac as a precursor of 223Ra was obtained. The results showed that with one month neutronbombardment of 2.5 mg 226Ra in TRR and cooling for 4 months, it is theoretically possible to achieveabout 8.51 MBq (0.23 mCi) activity of 223Ra, that with respect to injection of about 3.7 MBq (0.1 mCi) perpatient (with normally 70 kg weight), it is possible to administer the produced 223Ra to more than 2 patientsin every equilibrium period.

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