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Information Journal Paper

Title

CALMODULIN POTENTIATES THE ANTINOCICEPTIVE EFFECTS OF MORPHINE IN RATS

Pages

 Start Page 11 | End Page 18

Abstract

 Background and Objectives: CALMODULIN is involved in signaling pathways of opioid receptors. The present study was performed to determine the effect of chronic intracerebroventricular (ICV) administration of W-7, a specific CALMODULIN inhibitor, on the development of MORPHINE TOLERANCE.Materials and Methods: This experimental study was carried out on 75 male wistar rats weighing 200-250 g. The cannula was placed in the lateral ventricle of rat's brain according to the Paxinos and Watson atlas using the stereotaxic instrument. Rats were allowed a 7 day recovery period after the surgery for implantation of the cannula. MORPHINE was injected intraperitoneally based on a daily dose of 15mg/kg for 8 days. The development of TOLERANCE to analgesic effects of MORPHINE was measured on days 1, 3, 5 and 8 by Tail-Flick test. W-7 (0.25, 0.5 and 1micromol/rat) was injected as ICV each day 10 minutes prior the MORPHINE administration. On days that Tail-Flick test was performed W-7 was administered after the test.Results: Chronic administration of MORPHINE alone for 8 days induced TOLERANCE to its antinociceptive effect. ICV administration of W-7 in dose of 0.5 and 1 micomol/rat could prevent the development of MORPHINE TOLERANCE. However administration of W-7 in dose of 0.25 micomol/rat could not prevent the development of MORPHINE TOLERANCE.Conclusion: Chronic ICV administration of W-7 (a specific CALMODULIN inhibitor) inhibited the development of MORPHINE TOLERANCE. These results indicate that CALMODULIN and CALMODULIN- dependent pathways may play a role in the MORPHINE TOLERANCE process.

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