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Information Journal Paper

Title

THERMOSENSITIVE FOLIC ACID-TARGETED POLY (ETHYLENE-CO-VINYL ALCOHOL) HEMISUCCINATE POLYMERIC NANOPARTICLES FOR DELIVERY OF EPIRUBICIN TO BREAST CANCER CELLS

Pages

 Start Page 967 | End Page 976

Abstract

 A novel THERMOSENSITIVE folic acid (FA)-targeted succinylated poly (ethylene-co-vinyl alcohol) (EVOH) (EVOHS-FA) nanocarrier was synthesized for the specific delivery of epirubicin (EPI) to MCF-7 BREAST CANCER cell line. Three different ratios of synthesized EVOH-Suc were reacted with FA. The structure of the desired products (EVOHS40-FA, EVOHS60-FA and EVOHS80-FA) was confirmed by 1H NMR and FTIR techniques. Nanoparticles were obtained by nano-precipitation procedure using DMSO/H2O as solvent/anti-solvent. The particle size, zeta potential, entrapment efficacy and in vitro release profile of the final formulations in different temperatures were measured. The optimized nanoparticles had the particle size of 214 ± 8.5 nm, zeta potential of -29.6 mV, PDI of 0.198 ± 0.04, and a high encapsulation efficiency that released the drug efficiently within 450 h at the temperature of 40 °C compared to 37oC. The morphology of nanoparticles was studied by scanning electron microscopy. The in vitro cytotoxicity was evaluated using the MTT assay on MCF-7 cell lines in response to temperatures of 37 and 40oC. The MTT assay indicated that the targeted nanoparticles carrying EPI were significantly more cytotoxic than the non-targeted nanoparticles and the free drug at 40oC.

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