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Title

THE EFFECT OF HYDROALCOHOLIC EXTRACT OFNASTURTIUM OFFICINALIS ON OVARIAN HORMONAL AND HISTOLOGICAL CHANGES AFTER TOXICITY BY DOXORUBICIN IN RATS

Pages

 Start Page 953 | End Page 964

Abstract

 Background and Objectives: One of the side effects of chemotherapy is infertility and the use of NASTURTIUM OFFICINALIScauses the anticancer molecules to be increased. This study was conducted to determine the effect of hydroalcoholic extract of NASTURTIUM OFFICINALIS on ovarian changes after toxicity by DOXORUBICIN in RATs.Materials and Methods: In this experimental study, thirty-six mature, female Wistar RATs were randomized into six equal groups including groups, 1, 2, and 3 which received distilled water, 25 and 75 mg/kg of hydroalcoholic extracts ofNasturtium officinale daily for 21 days, respectively. Group 4 received only one single injection of DOXORUBICIN 10 mg/kg (IP) and groups 5 and 6 received DOXORUBICIN and 25 and 75 mg/kg of the extracts daily for 21 days, respectively. The Luteinizing HORMONE (LH) and FOLLICLE-stimulating HORMONE (FSH), estrogen, progesterone and ovarian histological changes and the ovaries weights were assessed at the end of the study.Data were analyzed using one- way ANOVA followed by Tukey's multiple comparisons test.Results: The mean (mean ± SD) of FSH in the second and third groups were 0.21±0.05 and 0.23±0.01 respectively, that significantly increased compared to the fourth group 0.11±0.01 (p<0.05). The mean of primary FOLLICLE in the fifth and sixth groups were 4.32±1.31 and 5.41±1.43, respectively, that didn' t show a significant increase compared to the fourth group 3.01±1.12, (p>0.05). The mean of graafian FOLLICLEs in the fifth and sixth groups signifantly increased compared to the fourth group (p<0.05).Conclusion: The hydroalcoholic extract of NASTURTIUM OFFICINALIS with antioxidant properties have efficacy on ovarian FOLLICLE to improve oogenesis following toxicity by DOXORUBICIN in RATs.

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