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Information Journal Paper

Title

INVESTIGATION ON GENE-ENVIRONMENT INTERACTION USING BREAST CANCER DATA; A CASE-ONLY AND CASE-CONTROL DESIGNS

Pages

 Start Page 267 | End Page 278

Abstract

 Background and Objectives: The role of GENE-ENVIRONMENT INTERACTION in epidemiology has been widely considered. The traditional methods of studying the GENE-ENVIRONMENT INTERACTION need appropriate control groups which their selection may be associated with some problems. Therefore, new methods have been created to study these interactions from which are the CASE-ONLY designs. In this method, only the cases data are being used. In this study, GENE-ENVIRONMENT INTERACTION in patients with BREAST CANCER was investigated using the CASE-ONLY and CASE-CONTROL designs.Material and Methods: This study conducted in 2008, using two methods: matched CASE-CONTROL and CASE-ONLY. Simple random sampling was used to select 300 patients with BREAST CANCER in Shahid Mottahari Clinic for two aforementhioned designs. The control group for the matched CASE-CONTROL study was selected from the women referring to Shahid Mottahari Clinic. Data were analysed using lagistic regressian and conditional logistic regression.Results: The confidence intervals and log likelihood in all variables in CASE-ONLY design was better than the matched CASE-CONTROL. In CASE-ONLY design, the standard error in the following variables; age at menarche, the first delivery at the age of ³34yrs and/or nulliparity, the number of live births, use of oral contraception pills, and breastfeeding history were less than those in the matched CASE-CONTROL design. In CASE-ONLY design, the P-value of the above-menthined variables was less than those of the matched CASE-CONTROL design.Conclusion: The CASE-ONLY design is an efficiency method for investigating of the interaction in terms of statistical study, sample size and the easily implementing.

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