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Title

HYPERHOMOCYSTEINEMIA, LOW VITAMIN B12, AND LOW FOLIC ACID: ARE RISK FACTORS OF CEREBRAL VASCULAR THROMBOSIS IN NORTHWEST IRAN?

Pages

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Keywords

CEREBRAL VASCULAR THROMBOSIS (CVT) 
HYPERHOMOCYSTEINEMIA (HYPER-HCYS) 

Abstract

 Background: Cerebral vascular thrombosis (CVT) is the thrombosis of intracranial and sinuses. The aim of this is to estimate of riskof low FOLIC ACID, low VITAMIN B12, and hyperhomocysteinemia (hyper-Hcys) for CVT. Materials and Methods: A total of 24 patientswith CVT and 36 healthy controls participated in a cross-sectional case-control study. The deficient levels of FOLIC ACID and vitaminB12 defined as<10th percentile of FOLIC ACID and VITAMIN B12 level and hyper-Hcys was defined as>90th percentile of homocysteineof control group.Results: Patients had higher levels of total homocysteine (tHcys) than controls (14.7 ± 6.5 vs.6.4 ± 2.7 μmol/L, P=0.001). Also, VITAMIN B12 level in case group was lower compared to control subjects (185.4 ± 58 vs.299 ± 75 ng/mL, P=0.001).Hyper-Hcys and low VITAMIN B12 were significantly more prevalent in CVT patients than controls. Although, significant independentassociation with risk of CVT was found for hyper-Hcys [adjusted odds ratio (OR) 14.3, 95% confidence interval (CI): 2.6-77.1, P=0.002] and low VITAMIN B12 (adjusted OR 24.6, 95% CI: 2.3-262.9, P=0.008). Association between low FOLIC ACID and risk of CVTwas not significant. A significant negative correlation was found between the levels of tHcys and VITAMIN B12 (r=−0.32, P=0.01).Conclusion: Hyper-Hcys and low VITAMIN B12 were related with the high risk for CVT.

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