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Title

MR ENTEROGRAPHY IN CELIAC DISEASE: CORRELATION WITH ENDOSCOPIC, HISTOPATHOLOGIC, SEROLOGIC AND GENETIC FEATURES

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Abstract

 Introduction: To determine bowel abnormalities of MR Enterography (MRE) in patients with Celiac disease (CD) and investigate their associations with endoscopic, histopathologic, serologic and genetic features.Methods: Forty consecutive new or poorly controlled adult patients with CD, aged 17-76 years, underwent MRE. Two radiologists evaluated qualitative and quantitative findings. Endoscopic manifestations were categorized into normal/mild (erythema, erosions) and severe (scalloping, villous atrophy).Histopathological results were divided into mild (Marsh 1, 2 and 3A) and severe (Marsh 3B, 3C).Genotyping of HLA-DQ2 and DQ8 was performed.Serum levels of tissue-trasnglutaminase, endomysial and gliadin antibodies were also determined.Results: Eleven (27.5%) cases showed unremarkable MRE. Fold reversal pattern was significantly associated with severe endoscopic (OR=8.38, 95%CI 1.7-40.5) and pathologic (OR=7.36, 95%CI 1.3-40.5) features. In multivariate regression analysis, increased numbers of ileal folds/inch were significantly associated with severe MARSH score (OR=2.83, 95%CI 1.4-5.5) and HLA-DQ8 (OR=1.11, 95%CI 1.06-3.2). Mean numbers of duodenal and jejunal folds/inch did not exhibit significant associations with endoscopic, pathologic, serologic and genetic features. Among quantitative measures, ileal fold number demonstrated to have the highest areas under the curve for prediction of severe endoscopic and pathologic findings and antitransglutaminase level.Conclusion: Fold reversal pattern in MRE is highly associated with severe endoscopic and pathologic features of CD. Increased ileal folds showed higher correlation with endoscopic-pathologic features, HLA-DQ8 and anti-transglutaminase level. MRE might be more sensitive for detection of increased ileal folds in CD rather than reduction of duodenal and jejunal folds due to better distension of ileal loops.

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    APA: Copy

    RADMARD, AMIR REZA, HASHEMI TAHERI, AMIRPEJMAN, SALEHIAN NIK, ELHAM, KOLAHDOOZAN, SHADI, MIRMINACHI, BABAK, EKHLASI, GOLNAZ, SOTOUDEH, MASOUD, SHAHBAZKHANI, BIJAN, & MALEKZADEH, REZA. (2015). MR ENTEROGRAPHY IN CELIAC DISEASE: CORRELATION WITH ENDOSCOPIC, HISTOPATHOLOGIC, SEROLOGIC AND GENETIC FEATURES. GOVARESH JOURNAL, 20(SUPPLEMENT), 0-0. SID. https://sid.ir/paper/698585/en

    Vancouver: Copy

    RADMARD AMIR REZA, HASHEMI TAHERI AMIRPEJMAN, SALEHIAN NIK ELHAM, KOLAHDOOZAN SHADI, MIRMINACHI BABAK, EKHLASI GOLNAZ, SOTOUDEH MASOUD, SHAHBAZKHANI BIJAN, MALEKZADEH REZA. MR ENTEROGRAPHY IN CELIAC DISEASE: CORRELATION WITH ENDOSCOPIC, HISTOPATHOLOGIC, SEROLOGIC AND GENETIC FEATURES. GOVARESH JOURNAL[Internet]. 2015;20(SUPPLEMENT):0-0. Available from: https://sid.ir/paper/698585/en

    IEEE: Copy

    AMIR REZA RADMARD, AMIRPEJMAN HASHEMI TAHERI, ELHAM SALEHIAN NIK, SHADI KOLAHDOOZAN, BABAK MIRMINACHI, GOLNAZ EKHLASI, MASOUD SOTOUDEH, BIJAN SHAHBAZKHANI, and REZA MALEKZADEH, “MR ENTEROGRAPHY IN CELIAC DISEASE: CORRELATION WITH ENDOSCOPIC, HISTOPATHOLOGIC, SEROLOGIC AND GENETIC FEATURES,” GOVARESH JOURNAL, vol. 20, no. SUPPLEMENT, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/698585/en

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