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Title

THE COMPARISON OF NEURO-PROTECTIVE EFFECTS OF TOTAL AQUA AND ETHANOL EXTRACTS OF SALVIA STAMINEA ROOT AND LEAVES ON CENTRAL DEGENERATION OF MOTONEURONS IN SPINAL CORD NEURONS FOLLOWING SCIATIC NERVE COMPRESSION IN WISTAR RATS

Pages

 Start Page 91 | End Page 99

Abstract

 Background: SALVIA STAMINEA, belonging to lamiaceae family, has positive effects on the nervous system and possesses anti-oxidant and anti-inflammatory effects. Hence, this study was conducted to determine the neuro-protective effects of salvia and its total ethanol extract on spinal cord motoneurons in Wistar rats.Materials and Methods:In an experimental trial, 54 male Wistar rats were divided into nine groups of six: Control, compression, treatment A (ethanol extract of root in 25, 50, and 75 mg/kg doses), treatment B (aqua extract of root in 25 and 50 mg/kg doses), treatment C (aqua extract of leaves in 50 mg/kg doses), and treatment D (ethanol extract of leaves in 75 mg/kg doses). In compression and treatment groups, 28 days after inducing impairment in α motoneurons, sampling of the left leg sciatic nerves was done in the rats. Following tissue passage, 7 micron cuts were obtained and painted with blue toluidine. Neuralgia motoneurons count was, then, carried out through steriology and dissector methods.Results: Neuron number density in the rats treated with 50 mg/kg doses of total aqua and ethanol extracts of leaves and 75 mg/kg dose of ethanol extract of root showed significant differences in comparison to that of the compression group (p<0.05).Conclusion: The results of this study prove the NEUROPROTECTIVE effects of these extracts on neuralgia motoneurons of spinal cord.

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