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Title

TO STUDY THE ASSOCIATION OF MIR-196A2 RS11614913 POLYMORPHISM WITH THE RISK OF IDIOPATHIC RECURRENT PREGNANCY LOSS

Pages

 Start Page 11 | End Page 17

Abstract

 Background: RECURRENT PREGNANCY LOSS (RPL) is defined as the occurrence of two or moreconsecutive pregnancy losses prior to 20th week of gestation. There are several leading causes of RPLincluding uterine anatomical defects, infections, genetic, immunological, and environmental factors.However, despite in a large number of cases no causes have been identified, therefore, it is introducedas idiopathic.Recent studies have implicated the role of MIRNAS in endometriosis, preeclampsia, infertility andRPL. Therefore, the aim of the present study was to investigate the association of miR-196a2C>T(rs11614913) with RPL in Iranian women.Materials and Methods: In this case-control study, 183 Iranian women including 83 patientswith at least two unexplained consecutive pregnancy losses and 100 healthy controls with at least onelive birth and no history of pregnancy loss were investigated. Patients with RECURRENT PREGNANCY LOSSesdue to anatomic, hormonal, chromosomal, infectious, autoimmune, or thrombotic causes wereexcluded from the study group. Genotyping was performed using Tetra- ARMS PCR method.Results: Significant difference in distribution of miR-196a2 rs11614913 genotypes was foundin RPL patients in comparison to controls, with p value of 0.04 and odds ratio equal to 2.96 (95% CI: 1.03-7.03).Conclusion: The results of the present study provide evidence for association between geneticvariation in miR-196a2 and RECURRENT PREGNANCY LOSS. Further studies will be required to validate thesignificance of the studied genetic variation in diverse populations and its regulatory role on targetgenes.

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