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Information Journal Paper

Title

PALIFERMIN AND CHLORHEXIDINE MOUTHWASHES IN PREVENTION OF CHEMOTHERAPY- INDUCED MUCOSITIS IN CHILDREN WITH ACUTE LYMPHOCYTIC LEUKEMIA: A RANDOMIZED CONTROLLED TRIAL

Pages

 Start Page 343 | End Page 347

Abstract

 Statement of the Problem: Over the past three decades, significant improvements have been achieved in the survival of children with cancer. However, the considerable morbidity which occurs as a result of chemotherapy often restricts the treatment intensity. One of the important dose-limiting and costly adverse effects of cancer therapy is mucositis. Children with hematological malignancies are greatly at risk of developing mucositis.Purpose: This study aimed to assess the effectiveness of PALIFERMIN in preventing mucositis in children with acute lymphocytic LEUKEMIA (ALL) who undergo chemotherapy.Materials and Method: In this clinical trial, 90 children with ALL were randomized to receive chlorhexidine (n=45) or PALIFERMIN (n=45). One group received 60 mg/ kg/ day PALIFERMIN as an intravenous bolus once daily for 3 days before and 3 days after the chemotherapy. Chlorhexidine mouthwash was administered once daily for 3 days before and 3 days after the chemotherapy. The world health organization (WHO) oral toxicity scale was employed for grading the mucositis. The data were analyzed by using two-way ANOVA.Results: The two groups were matched for age and gender. The study groups were significantly different in terms of mucositis grading (P values after 1 and 2 week therapy were 0.00). PALIFERMIN decreased the incidence and severity of chemotherapy-induced mucositis.Conclusion: PALIFERMIN reduces the ORAL MUCOSITIS in children with ALL. Several mechanisms of action are suggested for keratinocyte growth factor (such as PALIFERMIN) including promotion of cell proliferation and cytoprotection, restraining the apoptosis, and changing the cytokine profile.

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