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Title

ROLES OF OSTEOPONTIN AND MATRIX METALLOPROTEINASE-7 IN OCCURRENCE, PROGRESSION, AND PROGNOSIS OF NONSMALL CELL LUNG CANCER

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Keywords

MATRIX METALLOPROTEINASE-7 (MMP-7) 
NONSMALL CELL LUNG CANCER (NSCLC) 
OSTEOPONTIN (OPN) 
TUMOR NODE METASTASIS (TNM) STAGING 

Abstract

 Background: This study detected osteopontin (OPN) and matrix metalloproteinase-7 (MMP-7) expressions to explore the roles of OPN and MMP-7 in the occurrence, progression, and PROGNOSIS of nonsmall cell lung cancer (NSCLC). Materials and Methods: A retrospective study was conducted on NSCLC tissues (n=152; case group) and adjacent nonneoplastic lung parenchyma (adjacent to tumor>5 cm; n=152; control group) collected from 152 NSCLC patients. The protein expressions of OPN and MMP-7 were detected by immunohistochemistry. OPN and MMP-7 messenger RNA (mRNA) expressions were detected by reverse transcription polymerase chain reaction (RT-PCR).Results: The protein and mRNA expressions of OPN and MMP-7 in NSCLC tissues were evidently higher than those in adjacent nonneoplastic lung parenchyma (all P<0.05). OPN protein and mRNA expression were associated with the degree of differentiation, tumor node metastasis (TNM) staging, and LYMPH NODE METASTASIS in NSCLC (all P<0.05). MMP-7 protein expression was associated with TNM staging and LYMPH NODE METASTASIS (both P<0.05) while MMP-7 mRNA expression was associated with the degree of differentiation, TNM staging, and LYMPH NODE METASTASIS (all P<0.05). A significantly positive relativity was revealed between OPN expression and MMP-7 expression (protein: r=0.789, P<0.001; mRNA: r=0.377, P<0.001). LYMPH NODE METASTASIS, TNM staging, OPN, and MMP-7 protein expressions were independent risk factors for the PROGNOSIS of NSCLC (all P<0.05).Conclusion: High MMP-7 and OPN protein expressions are closely related to the occurrence, progression, and PROGNOSIS of NSCLC, and can be served as unfavorable prognostic factors for NSCLC.

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