Journal Paper

Paper Information

video

sound

Persian Version

View:

18,493

Download:

10,944

Cites:

Information Journal Paper

Title

FLIXWEED VS. POLYETHYLENE GLYCOL IN THE TREATMENT OF CHILDHOOD FUNCTIONAL CONSTIPATION: A RANDOMIZED CLINICAL TRIAL

Pages

 Start Page 1 | End Page 6

Abstract

 Background: POLYETHYLENE GLYCOL (PEG) is often considered as the first-line treatment for functional CONSTIPATION in CHILDREN. DESCURAINIA SOPHIA (L.) Webb et Berth (D. sophia) is a safe recommended medicine in Iranian folk and Traditional Persian Medicine for the treatment of CONSTIPATION.Objectives: To clinically compare D. sophia with PEG 4000 (without electrolyte) in pediatric CONSTIPATION and to assess its efficacy and side effects.Patients and Methods: 120 patients aged 2 - 12 years with CONSTIPATION for at least 3 months were included in an 8 weeks lasting randomized controlled trial within two parallel-groups. CHILDREN received either PEG, 0.4 g/kg/day, or D. sophia seeds, 2 grams (for CHILDREN aged 2 - 4 years) and 3 grams (for those aged>4 years) per day.Results: A total of 109 patients completed the study (56 in D. sophia and 53 in PEG group). At the end of the study, 36 (64.3%) patients in D. sophia group and 29 (54.7%) in PEG group were out of Rome III criteria (P=0.205). Median weekly stool frequency in 0, 1, 2, 3 weeks of the treatment was found to be 2, 5, 5, 5 in D. sophia and 3, 4, 4, 5 in PEG group (P=0.139, 0.076, 0.844, 0.294), respectively. The number of patients who suffered flatulence was less (5, 8.9%) in D. sophia group as compared to PEG group (6, 11.3%) at the end of the trial (P=0.461). D. sophia taste was less tolerated.Conclusions: D. sophia is introduced as a cheap and available medication which can be applied as a safe alternative to conventional PEG in the management of pediatric chronic functional CONSTIPATION.

Cites

  • No record.
  • References

    Related Journal Papers

  • No record.
  • Related Seminar Papers

  • No record.
  • Related Plans

  • No record.
  • Recommended Workshops