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Title

EVALUATION OF LIPID PROFILE CHANGES IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS

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 Start Page 44 | End Page 45

Abstract

 Background: Some infections in acute phase can lead to atherogenic changes in serum LIPID profile of patients. The present study examined the changes in LIPID profiles in children with infectious mononucleosis.Methods: In this prospective cross-sectional study, 36 children with acute infectious mononucleosis aged between 1 and 10 years were evaluated for serum levels of total cholesterol, HDL, LDL, and triglycerides at acute phase and 2 months after recovery respectively.Findings: 25 patients (69.4%) were males and the mean age of patients was 4.1±2.0 years. Mean serum total cholesterol level of the patients in the acute phase of illness was 149.5 ± 35.3mg/dl.2 months after recovery, the mean serum total cholesterol reached to 145.6±30.5mg/dl, which was not statistically different from the acute phase of the disease.However, serum levels of HDL cholesterol 2 months after recovery had increased significantly from the acute phase of the disease (37.9±9.2mg/dl vs.28.4±10.6mg/dl, respectively; P<0.0001). The mean values of serum LDL cholesterol in the children with infectious mononucleosis was significantly reduced 2 months after recovery (81.4±19.4mg/dl vs.92.6±28.8mg/dl, respectively; P<0.009). Furthermore, serum triglyceride level after recovery from illness (108.6±36.9mg/dl) was significantly reduced in compare with the acute phase (163.7±114.3mg/dl) (P<0.004).Conclusion: Children with infectious mononucleosis suffer from acute disease atherogenic changes in LIPID profiles in acute phase of the disease which will significantly improve 2 months after recovery. Thus, the LIPID profiles can be used for patient’s follow up in order to assess their infection improvement.

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