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Title

EFFECTS OF POMEGRANATE JUICE CONSUMPTION ON INFLAMMATORY MARKERS IN PATIENTS WITH TYPE 2 DIABETES: A RANDOMIZED, PLACEBO-CONTROLLED TRIAL

Pages

 Start Page 215 | End Page 220

Abstract

 Background: Diabetes causes the increased concentration of circulatory cytokines as a result of INFLAMMATION. Considering that POMEGRANATE juice (PJ) is known to have antioxidant and anti-inflammatory properties, the purpose of this study was to determine the effects of PJ consumption on markers of INFLAMMATION in patients with type 2 diabetes (T2D).Materials and Methods: In a randomized, double-blind clinical trial study, 50 patients with T2D (40-65 years old) were randomly assigned to one of two groups. Participants in each group received either 250 mL/day PJ or a control beverage for 12 weeks. Biochemical markers including fasting plasma glucose (FPG), insulin and inflammatory markers were assayed on the baseline and follow-up blood samples.Results: In all, 44 patients in two groups were included in the analysis: PJ (n=22) and placebo (n=22). After 12 weeks of intervention, in the PJ group, there were 32% and 30% significant decreases in plasma C-reactive protein (hs-CRP) and Interlukin-6, respectively (P<0.05). The mean±SD plasma interlukin-6 (7.1±5.6 vs. 11.9±14.4 mg/L) and hs-CRP (1791±1657 and 1953±1561 ng/mL) concentrations in the PJ group were significantly lower than the placebo group after intervention (P<0.05).Conclusion: PJ consumption by patients with T2D does not affect FPG or the insulin resistance index (HOMA-IR), whereas it does reduce Interlukin-6 and hs-CRP concentrations in plasma. Therefore, PJ consumption may have an anti-inflammatory effect in patients with T2D.

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