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Title

A SURVEY ON GUILLAIN-BARRE SYNDROME AMONG UNDER 15 YEAR OLD CHILDREN IN IRAN 2005-2012

Pages

 Start Page 68 | End Page 68

Abstract

 Background: GUILLAIN-BARRE SYNDROME is a postinfectious polyneuropathy involving mainly motor nerves. The PARALYSIS usually follows a nonspecific viral infection by about 10 days. Weakness usually begins in the lower extremities and progressively involves the trunk, the upper limbs, and finally the bulbar muscles. Proximal and distal muscles are involved relatively symmetrically, but asymmetry is found in 9% of patients. The onset is gradual and progresses over days or weeks. Bulbar involvement occurs in about half of cases. Respiratory insufficiency and death can result.Methods: This study was descriptive and cross-sectional.Data gathering was through AFP (Acute Flaccid PARALYSIS) surveillance system which is the surveillance strategy for poliomyelitis eradication.The World Health Organization recommends that countries conduct surveillance for AFP cases. The AFP case definition is: “all cases of PARALYSIS/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> ACUTE FLACCID PARALYSIS including GUILLAIN-BARRE SYNDROME, among children aged less than 15 years and all cases of suspected poliomyelitis among persons of any age.” All the hospitals, private clinics, physiotherapy and rehabilitation units and public health care centers all over the country were included in the sampling frame.Findings: In this study, 2373 cases of 4487 AFP cases (%53) were classified as GUILLAIN-BARRE SYNDROME.1326 cases (%56) were males and 1047 cases (%44) were females.98 cases (%4) were under 1 year old, 739 (%31) were 1-2 years old, 552 (%23) were 3-4 years old and 984 (%41) were 5 years old or more.759 cases (%32) were febrile at the onset of PARALYSIS. Occurrence of PARALYSIS was 535 (%23) in winter, 669 (%28) in spring, 562 (%24) in summer and 607 (%25) in autumn. PARALYSIS was asymmetric in 469 (%20) of cases and symmetric in 1904 (%80) of cases. The progression of PARALYSIS was rapid (less than 4 days) in 1869 (%79) of cases. Follow- up after 60 days revealed that 1561 (%66) of cases were completely recovered, PARALYSIS remained in 742 (%31) of cases, 34 cases (%1) were lost during follow- up and 36 (%1) of them died.Conclusion: This study reveals that GUILLAIN-BARRE SYNDROME is the leading cause of PARALYSIS/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> ACUTE FLACCID PARALYSIS among under 15 year old children. So, all cases of Guillain- Barre syndrome should be notified immediately to the nearest health center.

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