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Information Journal Paper

Title

CARDIOVASCULAR EFFECTS OF FINGOLIMOD: A REVIEW ARTICLE

Pages

 Start Page 119 | End Page 126

Abstract

 Multiple sclerosis (MS) is a chronic auto-immune disease. Most therapeutic strategies for treatment of this disease direct immune modulation and control of inflammatory processes. First-line therapeutic agents showed moderate efficacy and frequent side-effects with moderate efficacy in trials. Their parental administration and limited longterm adherence restrict their efficacy compared with second-line therapies. FINGOLIMOD as a second-line therapeutic agent has been shown to reduce annualized relapse rate, risk of disability progression and inflammatory activity of relapsing MS. Safety and efficacy FTY720: Safety and e: cacy issues are the main metrics for judgment of drug efficacy. In this article, we focus on cardiovascular e; ects of FTY720 treatment. E; ect of FTY720 on rate and rhythm, impact of FTY720 on endothelial cells, its atheroprotective effects, its effects on cardiac transplantation outcomes, vascular complications of FTY720, e; ects of FTY720 on endocrine functions and interaction of FTY720 with cardioactive agents are explained in this review article.

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