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Title

COPD AND ASTHMA: EFFECTS BEYOND THE RESPIRATORY SYSTEM (COMMENTARY PAPER)

Author(s)

BARNES PETER J.

Pages

  9-9

Keywords

Not Registered.

Abstract

 Asthma and COPD are multidimensional diseases, with several systemic manifestations and associations with a number of comorbid diseases. The most likely link between asthma and COPD and these extrapulmonary conditions is the spillover of inflammatory mediators from the lung, as systemic inflammation is associated with skeletal muscle wasting and cachexia as well as with cardiovascular, metabolic, and bone diseases. Asthma is characterized by chronic airway inflammation, and infiltration of T-lymphocytes, mast cells, eosinophils and monocytes/macrophages. This is associated with the increased expression of several inflammatory proteins, including cytokines, enzymes, receptors and adhesion molecules.

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