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Title

EFFECT OF VITAMIN SUPPLEMENTATION ON SERUM OXIDIZED LOW-DENSITY LIPOPROTEIN LEVELS IN MALE SUBJECTS WITH CARDIOVASCULAR DISEASE RISK FACTORS

Pages

 Start Page 958 | End Page 964

Abstract

 Objective(s): OXIDIZED LOW-DENSITY LIPOPROTEINs (ox-LDLs) appear to play a significant role in atherogenesis. In fact, circulating ox-LDL concentrations have been recognized as a risk factor for cardiovascular disease (CVD). The main objectives of this study were to assess the effects of antioxidant vitamins on ox-LDL as a biomarker of CVD in male subjects with CVD risk factors.Materials and Methods: The effect of antioxidant vitamins on ox-LDL as a biomarker of CVD in male subjects with CVD in male subjects with CVD risk factors at baseline and after 12 weeks of supplementation with VITAMIN E (400 IU), C (500 mg), b-carotene (15 mg), and the combined supplements (E, C, and b-carotene) respectively defined as group E, C, B and control group was considered as group P.Results: The mean values for ox-LDL at the baseline were 86.93±26.30 U/l in group C, 94.52±38.40 U/l in group E, 79.73±2.07 U/l in group B, 85.97±23.07 U/l in combined group, and 84.90±14.66 U/l in group P. After 12 weeks of intervention the percentage of changes for group C, group E, group B, COM group, and group P were (-18.32), (-2286), (-17.31), (-19.01) and (-2.0), respectively. Using Wilcoxon method, significant differences were detected in the mean ox-LDL concentrations of baseline and after intervention, values in the C, E, B and combined groups (P<005).Conclusion: This study illustrated that diet supplemented with VITAMIN C (500 mg), VITAMIN E (400 IU), b-carotene (15 mg), and the combination of these vitamins was associated with lower serum ox-LDL levels.

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