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Information Journal Paper

Title

FABRICATION OF BIODEGRADABLE POLY(D,L-LACTIDE-CO-GLYCOLIDE) NANOPARTICLES CONTAINING TAMOXIFEN CITRATE

Pages

 Start Page 437 | End Page 446

Abstract

 Biodegradable polymers have been extensively investigated as nano-carrier delivery systems in ANTI-CANCER therapy. The ANTI-CANCER drugs generally suffer from low aqueous solubility, short in vivo half-life and haphazard side effects. In this work, biodegradable poly(d,l-lactide-co-glycolide) NANOPARTICLEs (PLGA) containing TAMOXIFEN CITRATE as a model ANTI-CANCER drug were prepared using an o/w emulsification- solvent evaporation method. Dynamic light scattering (DLS), scanning electron microscopy (SEM) and analytical HPLC procedures were used to characterize the NANOPARTICLEs in terms of particle size, morphology and drug content. The characteristics of the NANOPARTICLEs including size, drug loading, and the efficiency of encapsulation were optimized by means of a full factorial experimental design over the influence of four different independent variables. Analyses of variance (ANOVA) were used to evaluate the optimized conditions for the preparation of NANOPARTICLEs. Based on the results, the most significant variables were homogenization speed and concentration of PLGA in organic phase with known total volume. Also, the interactions between the percentage of PVA and the amount of PLGA and organic phase volume were the most important cross-factor parameters. The optimum formulation condition with 192 nm mean size and 33 w/w% loading capacity was established by using 3 mg.mL-1 PLGA/dichloromethane in 7 w/v% PVA solution and 40% oil/water solvent ratio for emulsification at 24000 rpm homogenization rate. The results of this work facilitate the development of nano-carriers for tamoxifen delivery through optimization studies to control NANOPARTICLEs with specific properties and establish correlations between optimum production conditions and the required nano-carrier desired characteristics.

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