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Journal: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES | Year:2011 | Volume:14 | Issue:2 (49) | Start Page:116 | End Page:121

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Title

EFFECT OF AQUEOUS-ETHANOLIC EXTRACT FROM ROSA DAMASCENA ON GUINEA PIG ISOLATED HEART

Pages

 Start Page 116 | End Page 121

Abstract

 Objective(s) In the present study, the effects of AQUEOUS-ETHANOLIC EXTRACT from ROSA damascena on heart rate and contractility were examined. Materials and Methods Isolated GUINEA-PIG hearts were perfused through aorta in a Langendorff mode. Heart rate (HR) and contractility were determined in the presence of four concentrations of the extract (0.1, 0.2, 0.4 and 1.0 mg %) and isoprenaline (1, 10, 100 nM and 1  mM) in comparison with baseline values in the presence and absence of propranolol (n=10 for each group). Results Both isoprenaline and the extract caused increase in heart rate and contractility (P<0.05 to P<0.001). The percent increased in HR due to the final concentration of isoprenaline in the absence of propranolol was significantly greater than that of the extract (P<0.01). Propranolol caused significant reduction in both HR and contractility (P<0.05 for both) but this effect was significantly reversed by isoprenaline and the extract (P<0.05 to P<0.001). The percent increased in heart contractility due to the final concentration of the extract in the absence and presence of propranolol was significantly greater than that of isoprenaline (P< 0.05 for both cases). There was significant correlation between both HR and heart contractility with concentration of isoprenaline and the extract (P<0.05 to P<0.001). Conclusion In conclusion this study showed a relatively potent inotropic and chornotropic effect for ROSA damascena on isolated GUINEA-PIG heart.

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