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Title

CORONARY ANGIOGENESIS DURING EXPERIMENTAL HYPERTENSION: IS IT REVERSIBLE?

Pages

 Start Page 269 | End Page 275

Abstract

 BACKGROUND: We investigated coronary angiogenesis and serum vascular endothelial growth factor (VEGF) and its soluble receptor-1 (sFlt-1) concentrations in two-kidney one-clip (2K1C) hypertensive rats before and after reversal of HYPERTENSION.METHODS: The animal groups were: (i) sham-clipped for 12 weeks; (ii) 2K1C for 12 weeks; (iii) sham-clipped for 12 weeks and unclipped for 12 weeks; and (iv) 2K1C for 12 weeks and unclipped for 12 weeks. Blood samples were taken before experiments and after clipping and unclipping; capillary density was also evaluated.RESULTS: Our results showed that blood pressure in hypertensive animals was higher than sham group (175±10 vs. 110.3±11.3 mmHg; p<0.05). Unclipping significantly reduced blood pressure in hypertensive rats (p<0.05). Serum VEGF and sFlt-1 levels in hypertensive group were significantly lower than sham group (VEGF: 74.36±5.85 vs. 104.07±7.75 pg/ml; sFlt-1: 426.67±25.74 vs. 690.76±41.14 pg/ml, respectively; p<0.05). Unclipping in hypertensive animals increased serum VEGF and sFlt-1 concentrations (VEGF: 93.65±8.61 vs. 74.36±5.85 pg/ml; sFlt-1: 742.05±79.23 vs. 426.67±25.74 pg/ml, respectively; p<0.05). In hypertensive animals, capillary density in the heart was higher than sham group, non-significantly (p>0.05) and after unclipping, it reached to sham group level.CONCLUSIONS: It seems that changes in capillary density and serum VEGF and sFlt-1 concentrations in renovascular HYPERTENSION are reversible by removing the cause of HYPERTENSION and it shows the importance of early diagnosis and treatment of HYPERTENSION in clinical condition.

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