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Title

THE EFFECT OF FLAVONOID NARINGENIN ON CONTRACTILE RESPONSE OF THORACIC AORTA ISOLATED FROM DIABETIC RATS

Pages

 Start Page 144 | End Page 153

Abstract

 Background & Aims: Considering increasing incidence of cardiovascular disorders in DIABETES MELLITUS and some evidence on antioxidant and antidiabetic potentials of NARINGENIN, this study was conducted to evaluate the beneficial effects of 6-week administration of NARINGENIN on contractile reactivity of isolated thoracic AORTA in diabetic rats.Methods: Male Wistar rats were divided into control, NARINGENIN-treated control, diabetic and glibenclamide-treated, and NARINGENIN-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was administered (60 mg/Kg). NARINGENIN (10 mg/kg) was administered i.p. one week after diabetes induction in every other day intervals for 6 weeks. Serum glucose level was measured before NARINGENIN administration and at 6th week. Finally, contractile reactivity of thoracic aortic rings to KCl and phenylephrine (PE) was cumulatively determined.Results: Serum glucose level at week 6 showed a significant decrease in NARINGENIN-treated diabetic group compared to diabetics (P<0.01). In addition, NARINGENIN-treated diabetic group showed a significantly lower contraction to PE (P<0.05) as compared to diabetic group and such significant reduction was also observed for KCl (P<0.05). Meanwhile, there was also a significant difference between control and NARINGENIN-treated control groups regarding their contractile reactivity to PE (P<0.05).Conclusion: Subchronic administration of NARINGENIN for 6 weeks could exert an anti-hyperglycemic effect and lowers contractile responsiveness of thoracic AORTA rings to KCl and phenylephrine.

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