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Journal: CELL JOURNAL (YAKHTEH) | Year:2011 | Volume:12 | Issue:SUPPLEMENT 1 (THE 1ST INTERNATIONAL STUDENT CONGRESS ON CELL AND MOLECULAR MEDICINE) | Start Page:74 | End Page:75

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Title

IMMUNOLOGY AND IMMUNOTHERAPY: P-78: ASSOCIATION BETWEEN TIM-1 GENE POLYMORPHISMS WITH ALLERGIC RHINITIS AND SERUM IMMUNOGLOBULIN LEVELS

Pages

 Start Page 74 | End Page 75

Keywords

Abstract

 Objective: ALLERGIC RHINITIS is caused by the interaction of multiple genetic and environmental factors. One members of the T cell immunoglobulin domain and mucin domain (TIM) gene family, TIM-1, is located in the chromosome 5q31-33 region. This molecule has been involved in T-cell differentiation and implicated in allergic diseases. The aim of present study is to analyze the association between TIM-1 GENE POLYMORPHISMS with susceptibility to ALLERGIC RHINITIS, Serum IgE and IgA Levels in Iranian population.Materials and Methods: In a case–control study, 122 ALLERGIC RHINITIS patients and 130 allergy-free controls were recruited according to age and gender. We investigated two TIM-1 promoter single nucleotide polymorphisms (SNPs),−416G>C (rs9313422) and -1454G>A (rs41297579), by using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Additionally, the relationship between this SNPs and serum IgE and IgA levels in this population was also evaluated; Serum total IgE was measured by Enzyme-linked immunosorbent assay (ELISA) and Serum total IgA was measured by using Neflometry system. Statistical analysis was conducted with SPSS16.0 software.Results: We found that the -416G>C and -1454G>A SNPs were significantly associated with ALLERGIC RHINITIS susceptibility in our study population (odds ratio 2.73, 95% confidence interval 1.59-7.21; p=0.001 for-416) and (odds ratio 1.91, 95% confidence interval 1.29- 3.12; p=0.003 for-1454). In addition to, the serum IgE and IgA levels in the ALLERGIC RHINITIS subgroup with TIM-1 GENE POLYMORPHISMS were significantly higher than the ALLERGIC RHINITIS subgroup without this SNPs and the control group (p<0.05).Conclusion: Results suggest that the TIM-1 GENE POLYMORPHISMS (-416G>C and -1454G>A) are associated with the susceptibility of ALLERGIC RHINITIS and serum IgE and IgA levels, also has provided genetic data on TIM-1 gene in Iranian population and a basis for searching immune-mediated disease-related TIM-1 haplotype.

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