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Title

ROLE OF SYNBIOTICS IN THE TREATMENT OF CHILDHOOD CONSTIPATION: A DOUBLE-BLIND RANDOMIZED PLACEBO CONTROLLED TRIAL

Writers

KHODADAD A. | SABAGHIAN M.

Pages

 Start Page 387 | End Page 392

Abstract

 Objective: CONSTIPATION is a common problem in children. There is some clinical evidence for the role of PROBIOTICS and PREBIOTICS in the treatment of constipated children. This is the first study on the therapeutic effect of SYNBIOTICs (combination of PROBIOTICS and prebiotic) in treatment of childhood CONSTIPATION.Methods: In a double-blind randomized placebo controlled study 102 children aged 4–12 years with functional CONSTIPATION were assessed according to Rome III criteria for 4 weeks. They were divided into 3 groups: Group A, received 1.5 ml/kg/day oral liquid paraffin plus placebo, group B, 1 sachet SYNBIOTIC per day plus placebo and group C, 1.5 ml/kg/day oral liquid paraffin plus 1 sachet SYNBIOTIC per day. Frequency of bowel movements (BMs), stool consistency, number of fecal incontinence episodes, abdominal pain, painful defecation per week, success of treatment and side effects were determined in each group before and after treatment.Findings: The frequency of BMs per week increased in all groups (P<0.001), but it differed between groups and was higher in group C (P=0.03). Stool consistency increased and number of fecal incontinence episodes, abdominal pain and painful defecation per week decreased in all groups similarly and there was statistically no difference between them. No side effects were reported in group B; the main side effect in group A and C was seepage of oil (P<0.001). Treatment success was similar in all groups without any significant difference between them (P=0.6).Conclusion: This study showed that SYNBIOTICs have positive effects on symptoms of childhood CONSTIPATION without any side effects.

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