Journal Paper

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Journal: یاخته
Year:2010 | Volume: | Issue:
Start Page: | End Page:

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Title

POSTER PRESENTATIONS; HUMAN PLACENTA IS A POTENT HEMATOPOIETIC NICHE CONTAINING HEMATOPOIETIC STEM AND PROGENITOR CELLS THROUGHOUT DEVELOPMENT

Pages

 Start Page 42 | End Page 42

Abstract

 Objective: To determine if the HUMAN PLACENTA contains HEMATOPOIETIC STEM CELLS and if so when in DEVELOPMENT are they foundMaterials and Methods: HUMAN PLACENTAs from week 6 to term were obtained made into single cell suspensions for flow cytometric analysis, assessment of in vitro hematopoietic colony-forming ability, and hematopietic stem cell potential by in vivo xenotransplantation into immundeficient adult mice.Results: The HUMAN PLACENTA contains hematopoietic progenitors and HSCs from week 6 in gestation until term. Stromal cell lines generated from HUMAN PLACENTA at several DEVELOPMENTal time points are pericyte-like cells and support human hematopoiesis. Immunostaining of placenta sections during DEVELOPMENT localizes hematopoietic cells in close contact with PERICYTES/perivascular cells.Conclusion: The HUMAN PLACENTA is a potent hematopoietic niche containg hematopoietic stem and progenitor cells throughout DEVELOPMENT.

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