Journal Paper

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Journal: یاخته
Year:2011 | Volume: | Issue:
Start Page: | End Page:

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Title

EFFECT OF MELATONIN ON BONE MINERAL DENSITY OF IRRADIATED RATS

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 Start Page 459 | End Page 462

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Abstract

 Objective: MELATONIN is a powerful endogenous antioxidant and it may play a role in prevention of radiation-induced damage. The aim of this study was to investigate the effect of MELATONIN on BONE MINERAL DENSITY in RATs receiving radiation.Materials and Methods: Sprague Dawley RATs were divided into four groups. Group 1 (control group) received neither MELATONIN nor radiation (control group). Group 2 (Mel group) was administered intraperitoneal injections of 5mg/kg MELATONIN daily for ten days. Group 3 (RT group) and Group 4 were exposed to total cranium radiation of 5 Gy in a single dose by using a cobalt-60 teletherapy unit. In addition to IRRADIATION, group 4 (RT + Mel group) was administered 5mg/kg of MELATONIN intraperitoneally. At the end of the 10th day, the RATs' cranium and vertebrae bone mineral densities (BMDs) were measured.Results: When cranial BMDs were evaluated, statistically more significant BMD increases were seen in the Mel group and the RT + Mel groups than in the control group. No significant difference was seen in the Mel group versus the RT + Mel group; however, there was a significant difference between RT and RT + Mel groups. When vertebral BMDs were evaluated, the only significant difference was found between the control and Mel groups. Conclusion: We think that MELATONIN is a radioprotective agent. However, we would like to emphasize that further studies are needed before clinical trials with MELATONIN are initiated.

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