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Information Journal Paper

Title

SEROPREVALENCE OF BORDETELLA PERTUSSIS ANTIBODIES IN DIFFERENT AGE GROUPS

Pages

  43-47

Abstract

 Background and objective: Pertussis is a highly communicable, vaccine-preventable disease.The use of vaccines has reduced the disease but hasn't eliminated the circulation of BORDETELLA PERTUSSIS.In this study we determined the seroprevalence of antibodies against B. pertussis in different age groups in Tehran.Materials and methods: Plasma samples of 1101 subjects between ages of 8 months and 20 years were tested for the presence of pertussis toxin (PT), filamentous hemagglutinin (FHA) and different lipopolysaccharides (LPS) antibodies by ELISA. All cases vaccinated at least three times with DTwP in the first year of life, followed by two boosters at the age of 18 months and 4-6 years.Results: The overall prevalence of pertussis antibodies was 48% and the mean antibody level was 44±47.7 u/ml. Over half (53.1%) of the children aged 8 months to 6 years were negative for pertussis antibodies. Pertussis antibodies rates and levels were significantly different between age groups and their significant elevations were observed with increasing age.Conclusion: Our study showed that up to half of the vaccinated children lacked an antibody response to vaccine, so using a more immunogenic ally effective vaccine to ensure sufficient immunity is essential. Also we showed that B. pertussis infection is on the rise in Iranian adolescents and young adults. Booster vaccination of this age group appears to be the most logical approach to disease prevention in adolescents and control the circulation of the organism.

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