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Information Journal Paper

Title

A COMPARATIVE IMMUNOHISTO CHEMICAL DIAGNOSIS OF HODGKIN’S LYMPHOMA WITH CONVENTIONAL METHOD

Pages

 Start Page 214 | End Page 221

Abstract

 Introduction: LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA is a malignant neoplasm of B lymphocytes and less common T lymphocytes that morphologically can be mistaken with several benign and malignant diseases. These diseases have different course, treatments and prognosis from LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA. Immunohistochemical staining is very useful that will aid in separating LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA from a series of benign and malignant lookalikes.Materials and Methods: We Randomly selected 53 cases with primary diagnosis of LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA in pathology laboratory of Imam Reza Hospital from 1374-1384. To confirm or rule out of the primary diagnosis, microscopic evaluation and Immunohistochemical staining were done.Results: Overall in 47 cases (88.7%), LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA was confirmed and 6 cases (11.3%) were non hodgkin LYMPHOMA.A total 5 cases were T cell Rich large B cell LYMPHOMA and 1 case was anaplasic large cell LYMPHOMA probably. In LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA cases, the mean age was 40 years. Except for nodular sclerosis other types were more frequent in males. (M/F = 2.5).The commonest type was mixed cellularity (39 cases) (54.7%).Conclusion: Misdiagnosis of LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA without Immunohistochemical staining was 11.3%. Because of significant difference between treatment and prognosis of LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA and other morphologically similar diseases, immunohistochemical staining particulary in lymphocytic depletion and nodular lymphocytic predominant LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA, is necessary and recommended.

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