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Title

ANTIHYPERTENSIVE EFFECT OF LACTOFERRIN ON DEXAMETHASONE-INDUCED HYPERTENSION IN RAT

Pages

 Start Page 1096 | End Page 1104

Abstract

 Background: Dexamethasone-induced HYPERTENSION is one of the animal models of HYPERTENSION. LACTOFERRIN is a natural iron-binding protein with proposed antihypertensive effects. In this study, the effect of chronic use of LACTOFERRIN was investigated on dexamethasone-induced HYPERTENSION in rat and compared with captopril.Methods: In this experimental study, HYPERTENSION was induced by subcutaneously injection of dexamethasone (30 ±g/kg/day) for 15 days in Wistar rat. LACTOFERRIN (300 mg/kg) and captopril (40 mg/kg) were orally given from the day 8 to 15. Systolic blood pressure was measured by tail cuff. Body weight was measured during experiment and thymus weight was detected as a marker of GLUCOCORTICOID activity at the end of study. Findings: Administration of dexamethasone increased systolic blood pressure (115.6+3.3 to 150.1+7.4 mmHg) and decreased body and thymus weight (P<0.05). Chronic administration of LACTOFERRIN and captopril for one week decreased systolic blood pressure (P<0.01 for both). LACTOFERRIN also prevented body weight loss.Conclusion: The results indicated antihypertensive effect of LACTOFERRIN on dexamethasone-induced HYPERTENSION. Further studies are suggested for finding the mechanism of LACTOFERRIN in this model of HYPERTENSION.

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