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Title

THE EFFECTS OF ARSENIC ON THE SERUM TOTAL ALKALINE PHOSPHATASE (RELATED HIGH AND LOW MOLECULAR WEIGHT ISOENZYMES) CHANGES IN WISTAR RATS

Pages

 Start Page 56 | End Page 62

Abstract

 Background: ARSENIC is one of the toxic metals. And its accumulating in LIVER. The aim of this study was to evaluate the effects of ARSENIC on ALKALINE PHOSPHATASE activity and its high and low molecular isoenzymes as indexes for LIVER function. Methods: In this experiment 36 male Wistar rats were randomly allocated into six groups. In a short-term study animal were grouped as follow: group 1 control, group 2 and 3 received 40 and 80 mg/l as sodium. In a long-term period groups received half the dose of short-term period with oral administration. Blood samples were taken over a 15-day and 45-day period and serum enzyme ALKALINE PHOSPHATASE LIVER was measured and high and low molecular were isoenzymes were separated using with gel filtration chromatography technique the activity of low and high molecular weight ALKALINE PHOSPHATASE were measured by laboratory routine method. Results: The administration of four different doses of As sodium decreased the activity of serum total ALKALINE PHOSPHATASE compare to the control group. (P<0/05). and The activity of low and high molecular weight ALKALINE PHOSPHATASE 52% and 2% decreased compare to the control group. Conclusion: ARSENIC is able to decrease the ALKALINE PHOSPHATASE and thus can make damage to hepatocyts.

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