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Information Journal Paper

Title

SCOLICIDAL EFFECTS OF MIXTURE OF ARTEMISIA, EUCALYPTUS AND GINGER EXTRACTS ON HYDATID CYST PROTOSCOLICES

Pages

 Start Page 83 | End Page 91

Abstract

 Background and purpose: Hydatidosis is highly prevalent worldwide which mainly involvesliver and lung. There are some drugs sensitive to the hydatid disease but surgery is still the most commonform of treatment. Different chemical agents are used for inactivation of protoscolices during surgery butmost leave serious side effects. Therefore, herbal extracts have received more attention as replacingagents that have acceptable SCOLICIDAL effects and no adverse effects. The aim of this study was toinvestigate the SCOLICIDAL effects of mixture of ARTEMISIA, EUCALYPTUS and ginger extracts on HYDATID CYSTprotoscolices in vitro. Materials and methods: Hydatid liver cysts isolated from sheep were collected from aslaughterhouse in Hamedan, Iran. The cysts fluid containing live protoscolices were aspirated aseptically. The effect of two concentrations of the methanolic extracts of the mixture (50 and 100 mg/ml) wasinvestigated at 15 and 30 min. Viability of protoscolices was confirmed by 0. 1% eosin staining. Dataanalysis was done applying Chi-square test. Results: The mixture of EUCALYPTUS and ginger extracts showed acceptable SCOLICIDAL effects inwhich after 15 and 30 min exposure at 50 and 100 mg/ml concentrations it killed 97. 24% and 100% ofprotoscolices, respectively. Conclusion: This study showed that mixture of EUCALYPTUS and ginger had high SCOLICIDALactivity in vitro condition. Therefore, it could be used in surgical treatment of HYDATID CYST aftercomplementary researches.

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