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Information Journal Paper

Title

PHYLOGENETIC AND IN SILICO ANALYSIS OF INTERFERON BETA-1B PROTEIN

Pages

 Start Page 70 | End Page 82

Abstract

 Background and purpose: INTERFERON BETA-1B recombinant protein is used for reducing the relapse rate and treatment in patients with MULTIPLE SCLEROSIS (MS). In this study, phylogenetic and IN SILICO ANALYSIS of INTERFERON BETA-1B were conducted by servers and BIOINFORMATICS TOOLS to predict its structural potential.Materials and methods: Physiological and physico-chemical characteristics of interferon beta- 1b protein were evaluated by ProtScale and ProtParam servers, respectively. The 3D structure of the INTERFERON BETA-1B protein and its interaction with other proteins were studied using Swiss-Model server and the STRING platform, respectively.Results: The results of the phylogenetic analysis showed that the human interferon beta protein is closest to Daubenton's bat in the amino acid structure by 96%. The IN SILICO ANALYSIS of interferon beta 1b protein implied the existence of signal peptide and lack of the transmembrane domain. The results of post-translational modification predictions showed that protein acetylation and phosphorylation may occur in some regions of INTERFERON BETA-1B protein. The analysis of the protein networking of INTERFERON BETA-1B revealed more interactions between this protein and interferon receptor 1 (IFNAR1) and interferon regulatory factor 3 (IRF3).Conclusion: IN SILICO ANALYSIS showed that INTERFERON BETA-1B, is a protein with effective regulatory role but unstable in vitro. This bioinformatic analysis of INTERFERON BETA-1B protein can provide the groundwork for practical tests and future functional studies.

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