video

sound

Persian Version

View:

101

Download:

0

Cites:

Information Journal Paper

Title

FIRST LEAD STRUCTURE FOR NITROFURANTOIN RESISTANCE INHIBITION ACTIVITY AGAINST ENTEROBACTERIA

Author(s)

 SHAHVERDI A.R. | TAVASOULI F.

Pages

  0-0

Abstract

 We have previously shown that the ethanolic diluted essential oils of the aerial parts of Mentha longifolia could have NITROFURANTOIN resistance breaker activity against NITROFURANTOIN resistances Entherobacteriaceae. Bioassay-guided fractions of silica gel thin layer chromatography elute using the NITROFURANTOIN resistance test strains resulted one compound in active fraction containing a monoterpene PIPERITONE. PIPERITONE at the concentration of 1 mg/mL decreased MICs of all resistance strains to less than 32 µg/mL. In the presence of PIPERITONE the MICs of NITROFURANTOIN becomes about 8 times smaller than that of in its absence. Also it is found that in the presence of PIPERITONE the emergence of NITROFURANTOIN-resistant variants among wild type strains is completely suppressed. Taken together, these results indicate that PIPERITONE could have potential therapeutic effect on NITROFURANTOIN-resistance chemotherapy.

Cites

  • No record.

    • References

    Related Journal Papers

    Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    File Not Exists.