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Journal: گیاهان دارویی
Year:1381 | Volume:2 | Issue:5
Start Page:23 | End Page:30

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Title

FIRST LEAD STRUCTURE FOR NITROFURANTOIN RESISTANCE INHIBITION ACTIVITY AGAINST ENTEROBACTERIA

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Abstract

 We have previously shown that the ethanolic diluted essential oils of the aerial parts of Mentha longifolia could have NITROFURANTOIN resistance breaker activity against NITROFURANTOIN resistances Entherobacteriaceae. Bioassay-guided fractions of silica gel thin layer chromatography elute using the NITROFURANTOIN resistance test strains resulted one compound in active fraction containing a monoterpene PIPERITONE. PIPERITONE at the concentration of 1 mg/mL decreased MICs of all resistance strains to less than 32 µg/mL. In the presence of PIPERITONE the MICs of NITROFURANTOIN becomes about 8 times smaller than that of in its absence. Also it is found that in the presence of PIPERITONE the emergence of NITROFURANTOIN-resistant variants among wild type strains is completely suppressed. Taken together, these results indicate that PIPERITONE could have potential therapeutic effect on NITROFURANTOIN-resistance chemotherapy.

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