Journal Paper

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Journal: گیاهان دارویی
Year:1381 | Volume:2 | Issue:5
Start Page:13 | End Page:22

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Title

ANTICONVULSANT, HYPNOTIC AND MUSCLE RELAXANT EFFECTS OF CARBENOXOLONE, THE SYNTHETIC CONSTITUENT OF LICORICE IN MICE

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Abstract

 The ANTICONVULSANT, HYPNOTIC and MUSCLE RELAXANT effects of CARBENOXOLONE were studied in mice. In pentylenetetrazole test ED50 values of diazepam and CARBENOXOLONE were 1.13 mg/kg (95% CL: 0.89-1.44) and 283.3 mg/kg (95% CL: 144.27-556.29), respectively. In this test, CARBENOXOLONE in doses of 200 and 300 mg/kg prolonged the onset time of seizure and decreased the duration of seizures. CARBENOXOLONE induced a protective activity against seizure in comparison with diazepam (0.1, 0.5 mg/kg), but not a complete protection against mortality. ANTICONVULSANT efficacy of CARBENOXOLONE was similar as diazepam at a doses of 0-5 mg/kg. In maximal electroshock test, CARBENOXOLONE in a dose of 400 mg/kg decreased the duration of seizure and produced protection against seizure but failed to protect against mortality in comparison with diazepam (0.25, 0.5, 3 mg/kg). In the potentiation of pentobarbitone sleep test, CARBENOXOLONE signifiantly increased sleeping time and decreased latency dose dependently in of 100, 200, 300 mg/kg in mice. In traction test CARBENOXOLONE (400 mg/kg) showed MUSCLE RELAXANT activity (60%) and in accelerod performance CARBENOXOLONE in doses of 300, 200 mg/kg showed a decline in motor function. It can be concluded that CARBENOXOLONE posses ANTICONVULSANT, MUSCLE RELAXANT and HYPNOTIC effects which may be have an efficacy in petitmal and grandmal seizures.

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