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Title

THE EFFECT OF ARTICHOK LEAF EXTRACT ON ALANINE AMINOTRANSFERASE (ALT) AND ASPARTATE AMINOTRANSFERASE (AST) IN THE PATIENTS WITH NON ALCOHOLIC STEATOHEPATITIS (NASH)

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 Start Page 216 | End Page 216

Abstract

 Background: Based on recent basic and clinical investigations, the extract of artichoke (cynara scolymus) leaf has been revealed to be use as hepatoprotective, and cholesterol reducing purposes. We aimed to assess the therapeutic effects of artichoke on biochemical and LIVER biomarkers in patients with NON ALCOHOLIC STEATOHEPATITIS (NASH).Methods: In a randomized controlled trial, 60 consecutive patients suffered NASH were randomly assigned to receive SYNARA SCOLYMUS extract (as 6 tablets per day consisted of 2700 mg extract of the herb) as the intervention group or placebo as the control group for two months.Results: Comparing changes in study markers following interventions showed the improvement in body weight, body mass index, LIVER ENZYMEs, and also levels of triglyceride and cholesterol were significantly more in group treated with SYNARA SCOLYMUS when compared to placebo group. To compare the role of SYNARA SCOLYMUS use with placebo on changes in study parameters, multivariate linear regression models were employed indicating higher improvement in LIVER ENZYMEs and also LIPID profiles of triglyceride and total cholesterol following administration of SYNARA SCOLYMUS in comparison with placebo use.Conclusion: This study shed lights on the potential hepatoprotective activity and hypolipidemic effect of SYNARA SCOLYMUS in management of NASH.

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