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Title

THE EFFECT OF GARLIC ON PLASMA LIPID LEVELS IN PATIENTS WITH CORONARY ARTERY DISEASE

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 Start Page 183 | End Page 184

Abstract

 Background: Study was designed to estimate the effect of GARLIC powder tablets on the plasma LIPIDS in patients with CORONARY ARTERY DISEASE (CAD).Methods: A randomized, placebo-controlled, clinical trial was conducted on 56 CAD patients between the ages of 25 and 75 years. The patients were randomly divided into 2 groups: GARLIC groups (n=27), receiving GARLIC powder tablet (400 mg GARLIC) twice daily and the placebo groups (n=29), receiving placebo for 3 months. Fasting blood samples were taken before angioplasty (baseline) and after 3 months. Lipid levels were measured using commercially available kits and using a direct assay.Results: The mean age of 56 subjects was 59.37±1.28 years old. The frequencies of one, two and three vessel CAD were 61%, 35.1% and 3.9%, respectively. Plavix, aspirin, ACE inhibitor/ARB and atorvastatin were prescribed to all subjects of the study. After 3 months, lipid levels (included plasma total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides) increased in both groups. However, this increased trend in GARLIC group was lower compared to placebo group.There were no significant differences when mean changes in GARLIC-treated subjects were compared with mean changes in placebo-treated subjects.Conclusion: These results demonstrate that treatment with GARLIC-based drugs may be an effective treatment and considered as a safe adjunct treatment in CAD patients that undergoing angioplasty. The increase in lipid levels in our study can be related to different dosage of statin prescribed to patients before and after angioplasty. Future studies are recommended.

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