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Title

ROLE OF 11C-METHIONINE PET/CT FOR AMYGDALA ENLARGEMENT

Writers

ITO KIMITERU

Pages

 Start Page 56 | End Page 56

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Abstract

 The aim of this study is to explore amygdalar enlargement (AE) pathogenesis as one of the potential epileptogenic lesions by using 11Cmethionine (Met) positron emission tomography (PET) /computed tomography (CT). Forty-four patients with temporal lobe epilepsy (TLE) including twenty-six AE underwent Met PET/CT. Met uptake was visually assessed. AE were diagnosed with MRI findings by neuroradiologists. Seven of twenty-six AE cases showed Met positive. All TLE without AE cases showed Met negative. Lesion/normal ratio of Met uptake was significantly higher in the AE with Met positive group than in the AE with Met negative or TLE without AE groups. Finally, twelve patients underwent surgical treatment. Pathological evidence revealed 1 low grade glioma, 1 ganglioglioma, and 1 focal cortical dysplasia (FCD) in the AE with Met positive group, 2 FCD and 1 hamartoma in the AE with Met negative group, and 6 non-tumor lesions in the TLE without AE group. Met PET/CT can detect hidden brain tumors in TLE patients with AE.

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