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Title

INCREMENTAL VALUE OF STRESS-INDUCED DYSSYNCHRONY ON EARLY POST-STRESS TL- 201 GATED SPECT IN THE DIAGNOSIS OF CORONARY ARTERY DISEASE

Writers

HUNG GUANG UEI

Pages

 Start Page 51 | End Page 51

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Abstract

 Background: Previous studies showed different dyssynchrony patterns between ischemic and normal myocardium at early post-stress using Tl-201 gated SPECT. The aim of this study was to assess the relation of stress-induced dyssynchrony and the extent of coronary artery disease (CAD).Materials and Methods: 144 patients were retrospectively analyzed. With ³70% stenosis as the criteria of CAD, 57 had no CAD, 32 had 1-essel disease, 36 had 2-essel disease, and 19 had 3-essel disease, respectively. LV global and territorial dyssynchrony parameters were measured by the phase analysis from stress/rest Tl-01 SPECT and compared between stress and rest among the patient groups.Results: The patients with multi-vessel CAD had significantly more global dyssynchrony than the patients without ³70% stenosis at stress. In the patients with multi-essel CAD, stress images showed significantly more global and territorial dyssynchrony than the rest images. More patients with 3-essel CAD were correctly classified as multi-essel disease, when combining both visual interpretation and dyssynchrony assessment.Conclusion: The patients with multi-vessel CAD had significantly more global and territorial dyssynchrony at early post-stress than at rest. Such quantitative measures of myocardial stunning may assist in the diagnosis of multi-vessel CAD.

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