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Title

Unexplained High Activity of Aspartate Aminotransferase in an Asymptomatic Pediatric Patient

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 Start Page 5805 | End Page 5808

Abstract

 Elevated enzyme activities in plasma may at times be attributed to the presence of Macro-Enzymes. The Macro-Enzymes are often serum enzymes in complex with immunoglobulins, resulting in a greater molecular mass that cannot be filtered by renal glomeruli and are, hence, retained in the plasma. The Aspartate aminotransferase (AST) can exist as a macro-enzyme, although it has been rarely reported. We describe a pediatric patient with persistently elevated serum AST activity, due to macro-enzyme formation between AST and an immunoglobulin. This is to highlight the importance of early diagnosis of macro-AST in an otherwise asymptomatic pediatric patient with isolated AST-elevation and to avoid unnecessary costly testing.

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