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Title

Shiga Toxigenic Escherichia Coli Antimicrobial Resistance Properties in Diabetic and Nondiabetic Pediatric Patients; A Case-Control Study

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 Start Page 5999 | End Page 6008

Abstract

 Background Resistant Shiga toxigenic Escherichia coli (STEC), is the most prevalent source of Diarrhea in Pediatrics. This study was conducted to investigate the Antimicrobial resistance properties of STEC strains of diabetic and non-diabetic Pediatrics with Diarrhea. Materials and Methods: This was a case-control study conducted from December 2014 to September 2015 in an educational hospital, Jiroft city, Iran. Diarrheic stool samples were collected from diabetic (n= 385) and non-diabetic (n= 300) Pediatrics. The samples were cultured and the STEC strains were tested by disk diffusion and polymerase chain reaction (PCR) amplification were applied for detecting antibiotic resistance genes. Results Sampling was performed from 685 patients (51. 8% male). Total prevalence of STEC strains in diabetic and non-diabetic Pediatrics were 6. 5% and 3. 0%, respectively (P = 0. 007). Prevalence of the gens that encode resistance against ampicillin (CITM), fluoroquinolone (qnr), trimethoprim (dfrA1), tetracycline (tetA), gentamicin [aac(3)-IV] and sulfonamide (sul1) were 97. 1%, 64. 7%, 61. 8%, 58. 8%, 58. 3% and 52. 9%, respectively. Non-diabetic Pediatrics harbored the lower prevalence of antibiotic resistance genes (P = 0. 034). Conclusion High numbers of STEC, especially O157 strains, showed a multidrug-resistance against ampicillin, ciprofloxacin, gentamycin, sulfamethoxazole, and tetracycline. CITM, qnr, dfrA1, tetA, [aac(3)-IV] and sul1 antibiotic resistance genes were identified in the STEC strains of diarrheic samples of diabetic and non-diabetic pediatric patients.

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